The AML mutational landscape

The mutational landscape of hepatocellular carcinoma

The development of hepatocellular carcinoma (HCC) is a complex process, and HCC arises from the accumulation of multiple genetic alterations leading to changes in the genomic landscape. Current advances in genomic technologies have revolutionized the search for genetic alterations in cancer genomes. Recent studies in which all coding exons in HCC were sequenced have shed new light on the genomi...

Mutational landscape and underlying mutational processes in chronic lymphocytic leukemia

Sequencing studies have been instrumental in understanding the genetic basis of chronic lymphocytic leukemia (CLL). Our recent whole-genome sequencing study focusing on lower cytogenetic risk CLL demonstrated that CLL mutations can be attributed to 3 key mutational processes-2 types of activation induced-cytidine deaminase (AID) signatures and an aging signature-that operate at different times ...

Mutational landscape and response are conserved in peripheral blood of AML and MDS patients during decitabine therapy.

Mutational landscape of adult ETP-ALL

T-lineage acute lymphoblastic leukemia (TALL) accounts for approximately 25% of adult acute lymphoblastic leukemia. Improving therapy is a major challenge as outcome in adult TALL remains unsatisfactory for the majority of patients [1]. The subgroup of early T-cell precursor (ETP) ALL recently gained great interest [2] due to the fact that this subgroup in pediatric TALL patients was clinically...

Capturing the mutational landscape of the beta-lactamase TEM-1.

Adaptation proceeds through the selection of mutations. The distribution of mutant fitness effect and the forces shaping this distribution are therefore keys to predict the evolutionary fate of organisms and their constituents such as enzymes. Here, by producing and sequencing a comprehensive collection of 10,000 mutants, we explore the mutational landscape of one enzyme involved in the spread ...